Peroxisome-proliferator-activated receptor γ suppresses Wnt/β-catenin signalling during adipogenesis

Peroxisome-proliferator-activated receptor γ suppresses Wnt/β-catenin signalling during adipogenesis

The Wnt/β-catenin signalling pathway appears to operate to maintain the undifferentiated state of preadipocytes by inhibiting adipogenic gene expression. To define the mechanisms regulating suppression of Wnt/β-catenin signalling, we analysed the βcatenin expression in response to activation of transcription factors that regulate adipogenesis. The results show an extensive down-regulation of nu...

REVIEW Peroxisome proliferator-activated receptor- : from adipogenesis to carcinogenesis

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPARhas been reported to affect cell proliferation/ differentiation pathways in various malign...

Tudor-SN, a novel coactivator of peroxisome proliferator-activated receptor γ protein, is essential for adipogenesis.

Adipogenesis, in which mesenchymal precursor cells differentiate into mature adipocytes, is a well orchestrated process. In the present study we identified Tudor-SN as a novel co-activator of the transcription factor peroxisome proliferator-activated receptor γ (PPARγ). We provide the first evidence that Tudor-SN and PPARγ exist in the same complex. Both are up-regulated by the early factor C/E...

Peroxisome Proliferator-Activated Receptor

Peroxisome proliferator - activated receptor

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. The discovery of PPARγ as a target of multimodal insulin sensitizers has attracted remarkable scientific interest and had a great impact on the pharmaceutical industry. Thi...